"Spoštovani,

želela bi vas opozoriti na nedavna dogajanja v zvezi z Mpox, v zvezi z virusom Zahodnega Nila in v zvezi z ostalimi stvarmi.

Najprej si poglejmo dokument "Mpox global strategic preparedness and response plan", ki ga je nedavno izdala WHO.

Glej:

https://www.who.int/publications/m/item/mpox-global-strategic-preparedness-and-response-plan

Ta dokument med drugim govori o teh stvareh:

1) Dokument se nanaša na obdobje september 2024 - februar 2025. (Glej stran 4/27, 7/27, 24/27,)

Vir: https://cdn.who.int/media/docs/default-source/documents/health-topics/monkeypox/draft_sprp_mpox_2024.pdf?sfvrsn=6d9df725_3&download=true

2) Dokument na strani 24/27 med drugim omenja število testov na teden in število vakcinacij na teden.

3) Dokument na strani 16/27 omenja tri faze cepljenja.

4) V dokumentu je na strani 19/27 omenjenih naslednjih pet cepiv:

- MVA-BN

- LC16m8

- ACAM2000

- BNT166a

- BNT166c

Vir: https://cdn.who.int/media/docs/default-source/documents/health-topics/monkeypox/draft_sprp_mpox_2024.pdf?sfvrsn=6d9df725_3&download=true

Zdaj pa si poglejmo publikacijo Svetovne Zdravstvene Organizacije z naslovom “Pathogens prioritization: a scientific framework for epidemic and pandemic research preparedness”!

Glej:

https://www.who.int/publications/m/item/pathogens-prioritization-a-scientific-framework-for-epidemic-and-pandemic-research-preparedness

Publikacija je iz leta 2024.

V Table 1 med drugim pravijo, da je PHEIC risk za virus "Orthopoxvirus monkeypox" in za virus "Orthoflavivirus nilense" (kar je znanstveno ime za virus Zahodnega Nila) visok.

Vir:

Glejte stran 5/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

Poglejmo si še, kaj pravijo za druge patogene:

V Table 1 med drugim pravijo še, da je PHEIC Risk VISOK za naslednje patogene:

Mammarenavirus lassaense (ta virus je povezan z boleznimi "Arenaviral hemorrhagic fevers including Lassa Fever")

Mammarenavirus juninense

Mammarenavirus lujoense

Vibrio cholerae serogroup 0139

Yersinia Pestis

Shigella dysenteriae serotype 1

Salmonella enterica non typhoidal serovars

Klebsiella pneumoniae

Subgenus Merbecovirus (ta virus je povezan z boleznijo "Middle East Respiratory Syndrome")

Subgenus Sarbecovirus (ta virus je povezan z boleznimi "Other highly pathogenic coronaviral diseases such as Severe Acute Respiratory Syndrome")

Orthoebolavirus zairense (ta virus je povezan z boleznimi "Filoviral diseases Ebola")

Orthomarburgvirus marburgense (ta virus je povezan z boleznimi "Filoviral diseases Marburg ")

Orthoebolavirus sudanense

Orthoflavivirus zikaense (Zika virus)

Orthoflavivirus denguei

Orthoflavivirus flavi

Orthoflavivirus encephalitidis

Orthoflavivirus nilense (kar je znanstveno ime za virus Zahodnega Nila)

Orthohantavirus sinnombreense

Orthohantavirus hantanense

Orthonairovirus haemorrhagiae (ta virus je povezan z boleznijo "Crimean Congo Haemorrhagic Fever ")

Alphainfluenzavirus Influenzae H1

Alphainfluenzavirus Influenzae H2

Alphainfluenzavirus Influenzae H3

Alphainfluenzavirus Influenzae H5

Alphainfluenzavirus Influenzae H6

Alphainfluenzavirus Influenzae H7

Alphainfluenzavirus Influenzae H10

Henipavirus nipahense (ta virus je povezan z boleznimi "Nipah and related henipaviral diseases")

Bandavirus dabieense (ta virus je povezan z boleznijo "Severe Fever with Thrombocytopenia Syndrome ")

Phlebovirus riftense (ta virus je povezan z boleznijo "Rift Valley Fever")

Orthopoxvirus variola

Orthopoxvirus monkeypox

Alphavirus chikungunya

Alphavirus venezuelan

Vir:

Glejte stran 5/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

V Table 7 so med drugim omenjeni tudi naslednji patogeni:

Mastadenovirus blackbeardi 21

Mastadenovirus blackbeardi 55

Mastadenovirus blackbeardi 7

Orthoflavivirus nilense (kar je znanstveno ime za virus Zahodnega Nila)

Orthoebolavirus X

Alphainfluenzavirus influenzae (H9N2)

Enterovirus deconjucti 68

Enterovirus alphacoxsackie 71

Enterovirus-X

Orthopoxvirus cowpox

Vir:

Glejte stran 15/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

Še eno pojasnilo:

Izraz PHEIC pomeni "public health emergency of international concern".

Nazadnje je PHEIC bil razglašen 14. avgusta 2024 zaradi opičjih koz.

Glejte naslednji vir:

https://en.wikipedia.org/wiki/Public_health_emergency_of_international_concern#Clade_I_mpox_(2024%E2%80%93present)

Zdaj pa spregovorimo nekaj besed o koleri in še o nekaterih drugih važnih stvareh:

4. septembra 2024 je WHO objavila novico z naslovom "Data show marked increase in annual cholera deaths".

Vir: https://www.who.int/news/item/04-09-2024-data-show-marked-increase-in-annual-cholera-deaths

Naj vas spomnim na to, da je bila bakterija "Vibrio cholera (O139)" omenjena v Tabeli 4 v prej omenjenem dokumentu "Pathogens prioritization: a scientific framework for epidemic and pandemic research preparedness"!

V tej tabeli piše, da je PHEIC risk za bakterijo "Vibrio cholera (O139)" VISOK!!

V tej isti tabeli je v čisto desnemu stolpcu za bakterijo "Vibrio cholera (O139)" celo opomba "(Pandemic risk)"!!

V tej isti tabeli je v čisto desnemu stolpcu opomba "(Pandemic risk)" napisana tudi pri bakteriji "Yersinia pestis ", bakteriji "Shigella disenteriae serotype 1" in pri virusu "Alphavirus venezuelan"!!

Vir:

Glejte stran 12/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

Ali ste vedeli, da je bakterija "Vibrio cholerae serogroup O139" povezana z boleznijo "kolera"?

glej:

https://en.wikipedia.org/wiki/Vibrio_cholerae#Diversity_and_evolution

Zdaj pa spregovorimo nekaj besed o Influenza A virusih

4. septembra 2024 je WHO objavila "Disease Outbreak News" o virusu Influenza A(H1N1).

Vir: https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON532

Naj vas spomnim na to, da je bil virus "Alphainfluenzavirus influenzae (H1N1)" omenjen v Tabeli 4 v prej omenjenem dokumentu "Pathogens prioritization: a scientific framework for epidemic and pandemic research preparedness"!

V tej tabeli piše, da je PHEIC risk za virus "Alphainfluenzavirus influenzae (H1N1)" VISOK!!

Vir:

Glejte stran 12/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

2. septembra 2024 je WHO objavila "Disease Outbreak News" o virusu Influenza A(H5N1).

Vir: https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON533

Naj vas spomnim na to, da je bil virus "Alphainfluenzavirus influenzae (H5Nx)" omenjen v Tabeli 4 v prej omenjenem dokumentu "Pathogens prioritization: a scientific framework for epidemic and pandemic research preparedness"!

V tej tabeli piše, da je PHEIC risk za virus "Alphainfluenzavirus influenzae (H5Nx)" VISOK!!

Vir:

Glejte stran 12/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

Ali ste vedeli, da so v dokumentu "Summary of status of development and availability of variant1 influenza A(H1) candidate vaccine viruses and potency testing reagents", ki ga je objavila WHO, omenjeni takoimenovani "candidate vaccine viruses"?

Dovolite mi, da omenim le dva izmed teh "candidate vaccine viruses":

[(Antigenic prototype: A/Ohio/24/2017 (H1N2)v), (Candidate vaccine virus: IDCDC-RG59 ), (Type of virus or reassortant: Reverse genetics), (Developing institute: CDC, USA)]

[(Antigenic prototype: A/Ohio/9/2015 (H1N1)v), (Candidate vaccine virus: IDCDC-RG48A ), (Type of virus or reassortant: Reverse genetics), (Developing institute: CDC, USA )]

Vir:

https://cdn.who.int/media/docs/default-source/influenza/cvvs/cvv-zoonotic-northern-hemipshere-2023-2024/h1v_summary_a_h1v_cvv_20240223.pdf?sfvrsn=7880c599_1&download=true

Ali ste vedeli, da so v dokumentu "Summary of status of development and availability of A(H5N1) candidate vaccine viruses and potency testing reagents", ki ga je objavila WHO, omenjeni takoimenovani "candidate vaccine viruses"?

Dovolite mi, da omenim le dva izmed teh "candidate vaccine viruses":

[(Antigenic prototype: A/Vietnam/1194/2004), (Clade: 1 ), (Candidate vaccine virus: NIBRG-14), (Developing institute: MHRA, UK)]

[(Antigenic prototype: A/Vietnam/1203/2004), (Clade: 1 ), (Candidate vaccine virus: SJRG-161052), (Developing institute: CDC, USA SJCRH, USA HKU, China )]

vir:

https://cdn.who.int/media/docs/default-source/influenza/cvvs/cvv-zoonotic-northern-hemisphere-2024-2025/h5n1_summary_a_h5n1_cvv_20240223.pdf?sfvrsn=2d559bc4_5&download=true

Ali ste vedeli, da so v dokumentu "Summary of status of development and availability of avian influenza A(H7N9) candidate vaccine viruses and potency testing reagents", ki ga je objavila WHO, omenjeni takoimenovani "candidate vaccine viruses"?

Dovolite mi, da omenim le štiri izmed teh "candidate vaccine viruses":

[(Antigenic prototype: A/Gansu/23277/2019-like ), (Candidate vaccine virus: IDCDC-RG64A ), (Type of virus or reassortant: Reverse), (Developing institute: CDC, USA]

[(Antigenic prototype: A/Guangdong/17SF003/2016 ), (Candidate vaccine virus: NIBRG-375 ), (Type of virus or reassortant: Reverse genetics ), (Developing institute: MHRA, UK ]

[(Antigenic prototype: A/Shanghai/2/2013 ), (Candidate vaccine virus: CBER-RG4A ), (Type of virus or reassortant:Reverse genetics ), (Developing institute: CBER/FDA, USA]

[(Antigenic prototype: A/Anhui/1/2013), (Candidate vaccine virus: NIBRG-268 ), (Type of virus or reassortant:Reverse genetics ), (Developing institute:MHRA, UK ]

Vir:

https://cdn.who.int/media/docs/default-source/influenza/cvvs/cvv-zoonotic-northern-hemipshere-2023-2024/h7n9_summary_a_h7n9_cvv_-20240223.pdf?sfvrsn=862c0cce_1&download=true

Zdaj pa spregovorimo nekaj besed o izrazu "Dual Use Research of Concern"!

Ali ste vedeli, da je na spletni strani CDC, ki govori o "Dual Use Research of Concern" med drugim omenjen tudi "Reconstructed 1918 influenza virus"?

Ali ste vedeli, da so na spletni strani CDC, ki govori o "Dual Use Research of Concern" med drugim omenjeni tudi "Highly pathogenic avian influenza viruses"?

Ali ste vedeli, da "Reconstructed 1918 influenza virus" spada pod kategorijo "Dual Use Research of Concern"?

Ali ste vedeli, da "Highly pathogenic avian influenza viruses" spadajo pod kategorijo "Dual Use Research of Concern"?

Glejte naslednje vire:

spletna stran CDC z naslovom "Dual Use Research of Concern and Bird Flu: Questions & Answers":

Link: https://www.cdc.gov/flu/whatcdcdoes/analyze/dual-use-research.html#anchor_1492447874893

Članek na spletni strani WHO z naslovom "What is dual-use research of concern?":

Link do članka:

https://www.who.int/news-room/questions-and-answers/item/what-is-dual-use-research-of-concern

Zdaj pa spregovorimo nekaj besed o AMR in o bakteriji Klebsiella pneumoniae:

31. julija 2024 je WHO objavila "Disease Outbreak News" o AMR (Antimicrobial resistance) in bakteriji Klebsiella pneumoniae.

Vir:

Članek "Antimicrobial Resistance, Hypervirulent Klebsiella pneumoniae - Global situation":

Link do članka: https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON527

Naj vas spomnim na to, da je bila bakterija Klebsiella pneumoniae omenjena v Tabeli 1 v prej omenjenem dokumentu "Pathogens prioritization: a scientific framework for epidemic and pandemic research preparedness"!

V tej tabeli piše, da je PHEIC risk za bakterijo Klebsiella pneumoniae VISOK!!

Vir:

Glejte stran 5/38 na naslednji povezavi:

https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf?sfvrsn=c98effa7_7&download=true

Zdaj pa se spomnimo še na tri dokumente Evropske komisije, ki govorijo o AMR (antimicrobial resistance):

Glejte naslednje dokumente, še posebej prvi link:

https://health.ec.europa.eu/system/files/2023-11/amr-20230921-2_co01_en.pdf

https://health.ec.europa.eu/system/files/2023-11/amr-20230921-2_co02_en.pdf

https://health.ec.europa.eu/system/files/2023-11/amr-20230921-1_co07_en.pdf

Izmed teh treh dokumentov je potrebno izpostaviti prvega z naslovom "Possible European Commission information campaign on AMR", ki govori o takoimenovani “informacijski kampanji” za AMR (AMR pomeni odpornost na antibiotike oziroma antimikrobialna odpornost).

V temu dokumentu je na strani 7 omenjena fraza "Possible timeline". Na isti strani so omenjene fraze "Late Spring 2024" in "Micro comics launched".

Na strani 7 so omenjene tudi fraze "EAAD 2024 – end November" in "Campaign culminates".

Vir:

https://health.ec.europa.eu/system/files/2023-11/amr-20230921-2_co01_en.pdf

Zdaj pa spregovorimo nekaj besed o virusu Zahodnega Nila:

V zadnjemu času so mediji doma in po svetu nekaj poročali o virusu Zahodnega Nila.

Poglejmo si nekaj novic:

Tuji mediji:

https://www.cbsnews.com/newyork/news/nyc-west-nile-virus-mosquito-spraying-queens-lower-manhattan/

https://www.bbc.com/news/articles/c1ep24g99v3o

https://www.bbc.com/news/articles/c6280kxvxpro

Domači mediji:

https://www.rtvslo.si/zdravje/trije-primeri-okuzbe-z-virusom-zahodnega-nila-pacienti-niso-v-nevarnosti-gre-za-avtohtone-okuzbe/719762

https://www.rtvslo.si/zdravje/v-sloveniji-zaceli-testirati-kri-krvodajalcev-na-vsebnost-virusa-zahodnega-nila/719898

Ali ste vedeli, da je znanstveno ime za virus Zahodnega Nila "Orthoflavivirus nilense"?

Glej naslednji vir:

https://www.invasivespeciesinfo.gov/terrestrial/pathogens-and-diseases/west-nile-virus

Ali ste vedeli, da virus Zahodnega Nila pripada družini "flaviviridae"?

Glej:

https://en.wikipedia.org/wiki/West_Nile_virus

ALI SE ŽE RAZVIJAJO KAKŠNA “REŠILNA” CEPIVA ZA VIRUS ZAHODNEGA NILA?

Poglejmo si nekaj člankov:

"Preclinical and clinical development of a YFV 17 D-based chimeric vaccine against West Nile virus":

vir: https://pubmed.ncbi.nlm.nih.gov/24351795/

"A 20-year historical review of West Nile virus since its initial emergence in North America: Has West Nile virus become a neglected tropical disease?":

vir: https://pubmed.ncbi.nlm.nih.gov/33956816/

"Development of Vaccines against Emerging Mosquito-Vectored Arbovirus Infections":

vir: https://pubmed.ncbi.nlm.nih.gov/38250900/

Poglejmo si članek "Development of Vaccines against Emerging Mosquito-Vectored Arbovirus Infections" še enkrat!

V "Table 2 West Nile virus vaccine candidates tested in clinical trials.", so omenjena naslednja cepiva:

[(Vaccine Type: "Live Attenuated Chimeric" );(Vaccine name: "WN/DEN4-3′630 (NIAID, NIH)" )]

[(Vaccine Type: "Live Attenuated Chimeric" );(Vaccine name: "ChimeriVax-WN02, YFV, 17D backbone (Sanofi-Pasteur)" )]

[(Vaccine Type: "DNA" );(Vaccine name: "VRC-WNVDNA0l7-00-VP, first generation (NIAID, NIH, DVBD, CDC)" )]

[(Vaccine Type: "DNA" );(Vaccine name: "VRC-WNVDNA020-00-VP, second generation (NIAID, NIH)" )]

[(Vaccine Type: "Recombinant subunit" );(Vaccine name: "WN-80E (Hawaii Biotech)" )]

[(Vaccine Type: "Inactivated whole virus" );(Vaccine name: "HydroVax-001, hydrogen peroxide inactivated (Najit Technologies)" )]

[(Vaccine Type: "Inactivated whole virus" );(Vaccine name: "Formalin inactivated (Nanotherapeutics)" )]

vir: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10818606/

ALI STE VEDELI, DA SO V DOKUMENTU “Call for Applications for the Designation of an EU Reference Laboratory for Public Health in the field of Vector-borne viral pathogens” NA STRANI 7 OMENJENI IZRAZI “flaviviruses”, “West Nile virus”, “yellow fever virus” in “Zika virus”?

Dokument je dostopen na naslednjemu linku:

Source: https://health.ec.europa.eu/document/download/31937f75-8a09-46f9-b5b0-d8683a879c0d_en?filename=security_2023-eurl-call_vb-viral-pathogens_en.pdf

Ali ste vedeli, da je “West Nile virus (WNV)” na NIAIDovemu seznamu patogenov iz leta 2016 naveden v kategoriji B?

Glej:

NIAIDov seznam patogenov iz leta 2016:

https://web.archive.org/web/20180723110444/https://www.niaid.nih.gov/research/emerging-infectious-diseases-pathogens

Povzeto po:

https://justthinkinglogically844.wordpress.com/

Glede na vse zgoraj navedene podatke se mi zdi popolnoma logično, če se človek vpraša naslednje vprašanje:

Kaj lahko pričakujemo jeseni ali pa v obdobju po jeseni?

Zdi se mi, da so vse te informacije v tem trenutku zelo pomembne.

Lepo vas pozdravljam.

Anita"